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PDRN (Salmon DNA) Skin Regeneration

Regenerative polynucleotide injections that repair, hydrate and firm the skin.

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About PDRN (Salmon DNA) Treatment

PDRN (salmon DNA) treatment is a regenerative skin therapy that uses polydeoxyribonucleotide — purified DNA fragments derived from salmon — to repair and renew the skin from within. Delivered through fine microinjections, PDRN activates the skin's natural repair pathways, stimulating fibroblasts to produce fresh collagen and elastin while improving hydration and tone. Popularly known as the "salmon DNA facial", it is a favourite for restoring a healthy, firm and radiant complexion.

How PDRN Works

  • Stimulates fibroblast activity to rebuild collagen and elastin
  • Boosts deep hydration for plumper, smoother skin
  • Supports micro-circulation and tissue repair
  • Calms inflammation, helping skin recover and heal

Concerns & Areas Commonly Treated

  • Dull, dehydrated or tired-looking skin
  • Fine lines and early skin laxity
  • Uneven skin texture and tone
  • Delicate under-eye area
  • Neck and décolletage
  • Acne-scar healing support

Benefits

  • Regenerates skin at a cellular level for natural-looking results
  • Improves firmness, elasticity and hydration
  • Smooths fine lines and refines texture
  • Minimal downtime, suitable for most skin types

Treatment Overview

Treatment Time 30–45 minutes
Downtime Minimal (24–48 hours)
Recommended Course ~3 sessions, 2–4 weeks apart
When Results Start 1–2 weeks
Maintenance Every few months

Who It's for?

  • Anyone wanting healthier, more radiant skin
  • Early signs of ageing or loss of firmness
  • Dehydrated, dull or stressed skin
  • Those seeking natural regeneration over volume

Aftercare Instructions

  • Avoid makeup for the rest of the treatment day
  • Skip excessive heat, saunas and intense exercise for 24 hours
  • Keep skin hydrated and use daily sun protection
  • Avoid harsh actives (retinol, acids) for 48 hours

Additional Tips & Recommendations

  • Best results come from completing the full recommended course
  • Maintenance sessions help sustain regeneration over time
  • A healthy lifestyle and sun protection prolong your results
  • Combination treatments can enhance overall skin quality

PDRN is often combined with Microneedling, Profhilo, HIFU Face Lifting, and Dermal Fillers to improve skin quality and overall facial rejuvenation.

Learn More About Skin Rejuvenation

PDRN is one of several regenerative options for restoring skin health. Understanding how it compares to microneedling, skin boosters and other non-surgical treatments helps you choose what suits your skin best.

Non-Surgical Facial Treatments in Sri Lanka (2026 Guide)

Curious how collagen-stimulating treatments can refine texture and support acne-scar healing? Our microneedling guide explains the science and what to expect.

Microneedling in Sri Lanka: Benefits, Results & Safety

PDRN (Salmon DNA) Before & After

Real skin-regeneration results from a course of PDRN salmon DNA treatment at Elegance Aesthetic Clinic in Colombo. Drag the slider to compare before and after — notice the improved hydration, firmness and smoother, more radiant texture.

BEFORE
After PDRN salmon DNA treatment — firmer, hydrated and more radiant skin
Before PDRN salmon DNA treatment — dull, dehydrated skin with fine lines
AFTER

Individual results vary depending on skin type, concern and the number of sessions. Images are for illustration only.

FAQ

PDRN stands for Polydeoxyribonucleotide — a regenerative ingredient made from purified DNA fragments extracted from salmon. When injected into the skin it activates natural repair pathways, stimulating fibroblasts to produce fresh collagen and elastin, boosting hydration and supporting healing for healthier, firmer skin.

PDRN is highly purified and biocompatible, and the treatment is considered safe when performed by a qualified medical professional. We review your medical history at consultation first. It is not suitable for anyone with a known fish allergy and is avoided during pregnancy or breastfeeding.

The cost of PDRN treatment in Sri Lanka depends on the areas treated, the number of sessions in your plan and the product used. Because PDRN is usually done as a short course, accurate pricing is confirmed at a personalised consultation at our Colombo clinic.

Most patients have a course of about 3 sessions spaced roughly 2 to 4 weeks apart, followed by maintenance every few months. Your exact plan depends on your skin concern and goals, which are assessed at consultation.

Skin often looks more hydrated and radiant within one to two weeks. Firming and texture improvements build gradually over the treatment course as collagen production increases, with fuller results after your final session.

Downtime is minimal. Mild redness, small injection bumps or occasional pinpoint bruising may appear and usually settle within 24 to 48 hours. Most patients return to normal activities the same day.

PDRN is commonly used on the face, under-eye area and neck, and to support the healing of acne scars. It targets dull, dehydrated skin, fine lines, early laxity and uneven texture.

Skin boosters such as Profhilo mainly deliver hyaluronic acid for deep hydration and bio-remodelling, while PDRN focuses on cellular repair and collagen regeneration. They work well together, and your clinician can advise which combination suits your skin.

Yes. PDRN pairs well with microneedling, skin boosters, HIFU and dermal fillers as part of a wider rejuvenation plan. Combinations are planned during your consultation to keep treatments safe and effective.

PDRN should be administered by a qualified medical professional trained in facial anatomy and injection technique to ensure correct depth, placement and a safe, natural result.